Artemisinīna mākslīgās sintezēšanas process ir ne tikai sarežģīts, bet arī ar zemu ražu un augstu toksicitāti. Tāpēc pašreizējais artemisinīna piedāvājums tirgū galvenokārt tiek iegūts no Artemisia annua auga. Galvenās Artemisia annua aktīvo sastāvdaļu ekstrakcijas metodes ietver novārījumu, ekstrakciju ar atteci, ekstrakciju ar organisko šķīdinātāju, ekstrakciju ar ultraskaņu, ekstrakciju mikroviļņu krāsnī un CO2 superkritisko ekstrakciju.
The reflux extraction method is one of the common methods for extracting plant active ingredients. Using ethanol as the organic solvent for reflux extraction is easy to operate, has high extraction rate, and does not pollute the environment. When using reflux extraction to extract active ingredients from plants, solvent concentration, solid-liquid ratio, extraction temperature, extraction time, etc. are important factors that affect extraction efficiency. Wang Lifang and other scholars have shown that the optimal extraction process conditions for the active ingredients of Artemisia annua are 55% ethanol concentration, 95°C extraction temperature, 2 h extraction time, and a solid-liquid ratio of 1:8, with ethanol concentration and extraction temperature being the main influencing factors. , extraction time and solid-liquid ratio are secondary influencing factors. In this experiment, ethanol was selected as the extraction solvent, and the ethanol concentration, solid-liquid ratio, extraction temperature, and extraction time for extracting the active ingredients of Artemisia annua were optimized. The results show that the order of factors in extracting active ingredients of Artemisia annua by reflux extraction is ethanol concentration>extraction temperature>solid-liquid ratio>ekstrakcijas laiks, un optimālie ražošanas procesa parametri ir koncentrācija 65%, cietā šķidruma attiecība 1:8, Ekstrakcijas temperatūra 80 grādi un ekstrakcijas laiks 4 h, kas līdzinās iepriekšējo pētījumu rezultātiem.